Some immediate type reactions to amoxicillin and ampicillin are due to IgE ab directed at R group side chains. Selective allergy to aminopenicillins is less common in the US than allergy to beta lactam core ring structure..
More information about Type beta lactam allergy
Beta lactam antibiotic allergy continues to be a common form of adverse drug reactions. Drug allergy is often classified by the Gell and Coombs classification of hypersensitivity which consists of four types of reaction..As a response to the use of lactams to control bacterial infections, some bacteria have evolved penicillin binding proteins with novel structures. lactam antibiotics cannot bind as effectively to these altered PBPs, and, as a result, the lactams are less effective at disrupting cell wall synthesis..